Casdin Capital Portfolio
Casdin Capital 13F filer (CIK 0001534261).
Q3 2025 · 32 positions · Total reported value $1.20B · Top-10 concentration 84.5%
Turnover: 24.4% · 5 new · 3 cut · 3 exited
Active Share (vs S&P 500): 99.8% · vs QQQ: 99.9% — share of the book that differs from index weights (higher = more active) · ranking
In its Q3 2025 13F filing, Casdin Capital disclosed 32 equity positions with a combined reported value of $1.20B. The filing implies a focused portfolio: its ten largest positions account for 84.5% of reported value. HoldingsHub classifies the profile as Mid / Focused / Health Tilt / High Turnover.
The largest disclosed positions as of Q3 2025 were WGS ($323.99M), BLFS ($171.10M), RVMD ($123.63M). By sector, the heaviest allocations are Health Care 89.1%, Industrials 8.5%. Versus the prior quarter, allocation shifted toward Health Care (+3.7pp), Technology (+2.0pp) and away from Industrials (-1.5pp), Other (-4.2pp).
Versus the prior quarter, Casdin Capital opened 5 new positions, trimmed 3 and fully exited 3, a turnover rate of 24.4% of positions. The portfolio's overlap with the prior quarter was 71% of names.
Figures come from the fund's SEC Form 13F filing. 13F reports are filed within 45 days of quarter end and cover long positions of $100,000 or more; they exclude short positions and non-13F asset classes, so treat this page as a quarter-end snapshot rather than the fund's live book.
| # | Symbol | Company | Shares | Value | Weight | Change |
|---|---|---|---|---|---|---|
| 1 | WGS | GENEDX HOLDINGS CORP | 3.01M | $323.99M | 27.02% | Reduce |
| 2 | BLFS | BIOLIFE SOLUTIONS INC | 6.71M | $171.10M | 14.27% | Reduce |
| 3 | RVMD | REVOLUTION MEDICINES INC | 2.65M | $123.63M | 10.31% | Reduce |
| 4 | LAB | STANDARD BIOTOOLS INC | 77.56M | $100.83M | 8.41% | Add |
| 5 | RNA | ATRIUM THERAPEUTICS INC | 1.78M | $77.55M | 6.47% | Hold |
| 6 | RLAY | RELAY THERAPEUTICS INC | 11.34M | $59.20M | 4.94% | Reduce |
| 7 | ILMN | ILLUMINA INC | 525.00K | $49.86M | 4.16% | Reduce |
| 8 | GPCR | STRUCTURE THERAPEUTICS INC | 1.55M | $43.54M | 3.63% | Add |
| 9 | BEAM | BEAM THERAPEUTICS INC | 1.60M | $38.83M | 3.24% | Add |
| 10 | ALNY | ALNYLAM PHARMACEUTICALS INC | 55.00K | $25.08M | 2.09% | Reduce |
| 11 | TEM | TEMPUS AI INC | 294.13K | $23.74M | 1.98% | New |
| 12 | NGNE | NEUROGENE INC | 1.30M | $22.45M | 1.87% | Hold |
| 13 | MAZE | MAZE THERAPEUTICS INC | 758.86K | $19.68M | 1.64% | Hold |
| 14 | PRME | PRIME MEDICINE INC | 3.17M | $17.55M | 1.46% | Add |
| 15 | SPRY | ARS PHARMACEUTICALS INC | 1.60M | $16.08M | 1.34% | New |
| 16 | HIMS | HIMS & HERS HEALTH INC | 230.00K | $13.05M | 1.09% | Hold |
| 17 | DNLI | DENALI THERAPEUTICS INC | 890.00K | $12.92M | 1.08% | Hold |
| 18 | SEPN | SEPTERNA INC | 553.27K | $10.41M | 0.87% | Hold |
| 19 | VCYT | VERACYTE INC | 276.31K | $9.49M | 0.79% | Hold |
| 20 | UNH | UNITEDHEALTH GROUP INCORPORATED | 25.00K | $8.63M | 0.72% | New |
| 21 | INCY | INCYTE CORP | 100.00K | $8.48M | 0.71% | New |
| 22 | GH | GUARDANT HEALTH INC | 100.00K | $6.25M | 0.52% | Hold |
| 23 | EXAS | EXACT SCIENCES CORP | 90.00K | $4.92M | 0.41% | Hold |
| 24 | BBOT | BRIDGEBIO ONCOLOGY THERAPEUT | 282.31K | $3.27M | 0.27% | New |
| 25 | ABSI | ABSCI CORPORATION | 973.26K | $2.96M | 0.25% | Hold |
| 26 | CTNM | CONTINEUM THERAPEUTICS INC | 148.33K | $1.74M | 0.14% | Hold |
| 27 | PACB | PACIFIC BIOSCIENCES CALIF IN | 723.77K | $926.42K | 0.08% | Hold |
| 28 | RXRX | RECURSION PHARMACEUTICALS IN | 165.32K | $806.78K | 0.07% | Hold |
| 29 | GLUE | MONTE ROSA THERAPEUTICS INC | 86.01K | $637.36K | 0.05% | Hold |
| 30 | IPSC | CENTURY THERAPEUTICS INC | 1.23M | $611.64K | 0.05% | Hold |
| 31 | TNYA | TENAYA THERAPEUTICS INC | 361.97K | $586.39K | 0.05% | Hold |
| 32 | DNA | GINKGO BIOWORKS HOLDINGS INC | 36.49K | $532.07K | 0.04% | Hold |