Casdin Capital Portfolio
Casdin Capital 13F filer (CIK 0001534261).
Q1 2022 · 46 positions · Total reported value $2.21B · Top-10 concentration 55.7%
Turnover: 24.4% · 5 new · 3 cut · 3 exited
Active Share (vs S&P 500): 99.8% · vs QQQ: 99.9% — share of the book that differs from index weights (higher = more active) · ranking
In its Q1 2022 13F filing, Casdin Capital disclosed 46 equity positions with a combined reported value of $2.21B. The filing implies a moderately concentrated portfolio: its ten largest positions account for 55.7% of reported value. HoldingsHub classifies the profile as Mid / Health Tilt / High Turnover.
The largest disclosed positions as of Q1 2022 were BLFS ($171.98M), ALNY ($163.29M), EQRX ($163.25M). By sector, the heaviest allocations are Health Care 61.2%, Industrials 4.1%. Versus the prior quarter, allocation shifted toward Health Care (+5.2pp) and away from Industrials (-5.2pp).
Versus the prior quarter, Casdin Capital opened 5 new positions, trimmed 3 and fully exited 3, a turnover rate of 24.4% of positions. The portfolio's overlap with the prior quarter was 81% of names.
Figures come from the fund's SEC Form 13F filing. 13F reports are filed within 45 days of quarter end and cover long positions of $100,000 or more; they exclude short positions and non-13F asset classes, so treat this page as a quarter-end snapshot rather than the fund's live book.
| # | Symbol | Company | Shares | Value | Weight | Change |
|---|---|---|---|---|---|---|
| 1 | BLFS | BIOLIFE SOLUTIONS INC | 7.57M | $171.98M | 7.77% | Hold |
| 2 | ALNY | ALNYLAM PHARMACEUTICALS INC | 1.00M | $163.29M | 7.38% | Hold |
| 3 | EQRX | EQRX INC | 39.53M | $163.25M | 7.38% | Hold |
| 4 | FATE | FATE THERAPEUTICS INC | 3.40M | $131.82M | 5.96% | Hold |
| 5 | RLAY | RELAY THERAPEUTICS INC | 3.86M | $115.45M | 5.22% | Hold |
| 6 | SLGC | SOMALOGIC INC | 12.39M | $99.36M | 4.49% | Hold |
| 7 | BPMC | BLUEPRINT MEDICINES CORP | 1.55M | $99.01M | 4.47% | Hold |
| 8 | MXCT | MAXCYTE INC | 13.97M | $97.66M | 4.41% | Hold |
| 9 | NVTAQ | INVITAE CORP | 12.20M | $97.26M | 4.39% | Hold |
| 10 | EXAS | EXACT SCIENCES CORP | 1.33M | $92.99M | 4.20% | Reduce |
| 11 | PACB | PACIFIC BIOSCIENCES CALIF IN | 7.99M | $72.72M | 3.29% | Hold |
| 12 | VERV | VERVE THERAPEUTICS INC | 3.14M | $71.61M | 3.24% | Hold |
| 13 | ABSI | ABSCI CORPORATION | 7.72M | $65.07M | 2.94% | Hold |
| 14 | SRPT | SAREPTA THERAPEUTICS INC | 800.00K | $62.50M | 2.82% | Reduce |
| 15 | AGIO | AGIOS PHARMACEUTICALS INC | 2.09M | $60.84M | 2.75% | Hold |
| 16 | RVMD | REVOLUTION MEDICINES INC | 2.37M | $60.46M | 2.73% | Hold |
| 17 | DNLI | DENALI THERAPEUTICS INC | 1.50M | $48.26M | 2.18% | Hold |
| 18 | BEAM | BEAM THERAPEUTICS INC | 818.82K | $46.92M | 2.12% | Hold |
| 19 | GBT | GLOBAL BLOOD THERAPEUTICS IN | 1.32M | $45.90M | 2.07% | Hold |
| 20 | TWST | TWIST BIOSCIENCE CORP | 880.00K | $43.45M | 1.96% | Add |
| 21 | CDNA | CAREDX INC | 1.15M | $42.66M | 1.93% | Hold |
| 22 | TNYA | TENAYA THERAPEUTICS INC | 3.59M | $42.25M | 1.91% | Hold |
| 23 | TNGX | TANGO THERAPEUTICS INC | 5.49M | $41.60M | 1.88% | Hold |
| 24 | IPSC | CENTURY THERAPEUTICS INC | 3.21M | $40.37M | 1.82% | Hold |
| 25 | ONC | BEONE MEDICINES LTD | 150.00K | $28.29M | 1.28% | Hold |
| 26 | GH | GUARDANT HEALTH INC | 420.00K | $27.82M | 1.26% | Reduce |
| 27 | DMTKQ | DERMTECH INC | 1.75M | $25.62M | 1.16% | Hold |
| 28 | WGS | GENEDX HOLDINGS CORP | 5.00M | $15.35M | 0.69% | Hold |
| 29 | ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 1.00M | $13.88M | 0.63% | Hold |
| 30 | GLUE | MONTE ROSA THERAPEUTICS INC | 960.88K | $13.47M | 0.61% | Hold |
| 31 | SEER | SEER INC | 800.00K | $12.19M | 0.55% | Hold |
| 32 | TSVT | 2SEVENTY BIO INC | 614.75K | $10.49M | 0.47% | New |
| 33 | EXAI | EXSCIENTIA PLC | 713.90K | $10.28M | 0.46% | Hold |
| 34 | GBIO | GENERATION BIO CO | 1.32M | $9.72M | 0.44% | Hold |
| 35 | SNCE | SCIENCE 37 HOLDINGS INC | 1.80M | $9.63M | 0.43% | Hold |
| 36 | OMIC | SINGULAR GENOMICS SYSTEMS IN | 1.44M | $9.11M | 0.41% | Hold |
| 37 | MRTX | MIRATI THERAPEUTICS INC | 102.50K | $8.43M | 0.38% | New |
| 38 | FDMT | 4D MOLECULAR THERAPEUTICS IN | 555.46K | $8.40M | 0.38% | Hold |
| 39 | MGTA | MAGENTA THERAPEUTICS INC | 2.77M | $8.04M | 0.36% | Reduce |
| 40 | ZLAB | ZAI LAB LTD | 150.00K | $6.60M | 0.30% | Hold |
| 41 | CDXS | CODEXIS INC | 300.00K | $6.19M | 0.28% | Reduce |
| 42 | KRON | KRONOS BIO INC | 583.44K | $4.22M | 0.19% | Hold |
| 43 | RXRX | RECURSION PHARMACEUTICALS IN | 548.16K | $3.92M | 0.18% | Hold |
| 44 | ORIC | ORIC PHARMACEUTICALS INC | 601.51K | $3.21M | 0.14% | Hold |
| 45 | DBTX | DECIBEL THERAPEUTICS INC | 330.00K | $1.00M | 0.04% | Reduce |
| 46 | LIANY | LIANBIO | 206.41K | $766.00K | 0.04% | Hold |