Casdin Capital Portfolio
Casdin Capital 13F filer (CIK 0001534261).
Q4 2024 · 38 positions · Total reported value $1.50B · Top-10 concentration 78.8%
Turnover: 24.4% · 5 new · 3 cut · 3 exited
Active Share (vs S&P 500): 99.8% · vs QQQ: 99.9% — share of the book that differs from index weights (higher = more active) · ranking
In its Q4 2024 13F filing, Casdin Capital disclosed 38 equity positions with a combined reported value of $1.50B. The filing implies a focused portfolio: its ten largest positions account for 78.8% of reported value. HoldingsHub classifies the profile as Mid / Focused / Health Tilt / High Turnover.
The largest disclosed positions as of Q4 2024 were WGS ($269.56M), BLFS ($226.04M), RVMD ($161.81M). By sector, the heaviest allocations are Health Care 82.8%, Industrials 11.0%. Versus the prior quarter, allocation shifted toward Health Care (+0.7pp) and away from Other (-0.7pp).
Versus the prior quarter, Casdin Capital opened 5 new positions, trimmed 3 and fully exited 3, a turnover rate of 24.4% of positions. The portfolio's overlap with the prior quarter was 82% of names.
Figures come from the fund's SEC Form 13F filing. 13F reports are filed within 45 days of quarter end and cover long positions of $100,000 or more; they exclude short positions and non-13F asset classes, so treat this page as a quarter-end snapshot rather than the fund's live book.
| # | Symbol | Company | Shares | Value | Weight | Change |
|---|---|---|---|---|---|---|
| 1 | WGS | GENEDX HOLDINGS CORP | 3.51M | $269.56M | 17.94% | Hold |
| 2 | BLFS | BIOLIFE SOLUTIONS INC | 8.71M | $226.04M | 15.04% | Hold |
| 3 | RVMD | REVOLUTION MEDICINES INC | 3.70M | $161.81M | 10.77% | Reduce |
| 4 | SRPT | SAREPTA THERAPEUTICS INC | 1.07M | $130.53M | 8.69% | Hold |
| 5 | LAB | STANDARD BIOTOOLS INC | 71.25M | $124.70M | 8.30% | Hold |
| 6 | ILMN | ILLUMINA INC | 750.00K | $100.22M | 6.67% | Hold |
| 7 | RNA | ATRIUM THERAPEUTICS INC | 2.04M | $59.47M | 3.96% | Reduce |
| 8 | CDXS | CODEXIS INC | 8.10M | $38.64M | 2.57% | Hold |
| 9 | RLAY | RELAY THERAPEUTICS INC | 8.95M | $36.87M | 2.45% | Reduce |
| 10 | EXAS | EXACT SCIENCES CORP | 650.00K | $36.52M | 2.43% | Hold |
| 11 | ALNY | ALNYLAM PHARMACEUTICALS INC | 140.00K | $32.94M | 2.19% | Reduce |
| 12 | BEAM | BEAM THERAPEUTICS INC | 1.25M | $31.00M | 2.06% | Add |
| 13 | NGNE | NEUROGENE INC | 1.30M | $29.61M | 1.97% | Add |
| 14 | BPMC | BLUEPRINT MEDICINES CORP | 326.38K | $28.47M | 1.89% | Hold |
| 15 | NTLA | INTELLIA THERAPEUTICS INC | 2.00M | $23.32M | 1.55% | Hold |
| 16 | VERV | VERVE THERAPEUTICS INC | 4.00M | $22.54M | 1.50% | Hold |
| 17 | DNLI | DENALI THERAPEUTICS INC | 990.00K | $20.18M | 1.34% | Hold |
| 18 | GPCR | STRUCTURE THERAPEUTICS INC | 700.00K | $18.98M | 1.26% | Hold |
| 19 | MRNA | MODERNA INC | 350.00K | $14.55M | 0.97% | New |
| 20 | SEPN | SEPTERNA INC | 553.27K | $12.67M | 0.84% | New |
| 21 | VCYT | VERACYTE INC | 276.31K | $10.94M | 0.73% | Reduce |
| 22 | GH | GUARDANT HEALTH INC | 350.00K | $10.69M | 0.71% | Hold |
| 23 | TNYA | TENAYA THERAPEUTICS INC | 6.73M | $9.63M | 0.64% | Hold |
| 24 | AGIO | AGIOS PHARMACEUTICALS INC | 250.00K | $8.21M | 0.55% | New |
| 25 | FDMT | 4D MOLECULAR THERAPEUTICS IN | 1.15M | $6.41M | 0.43% | Hold |
| 26 | SNDX | SYNDAX PHARMACEUTICALS INC | 475.00K | $6.28M | 0.42% | Hold |
| 27 | TSVT | 2SEVENTY BIO INC | 2.00M | $5.88M | 0.39% | Hold |
| 28 | IPSC | CENTURY THERAPEUTICS INC | 5.19M | $5.24M | 0.35% | Add |
| 29 | FTRE | FORTREA HLDGS INC | 275.00K | $5.13M | 0.34% | New |
| 30 | CTNM | CONTINEUM THERAPEUTICS INC | 296.67K | $4.35M | 0.29% | Hold |
| 31 | TNGX | TANGO THERAPEUTICS INC | 1.19M | $3.67M | 0.24% | Hold |
| 32 | ABSI | ABSCI CORPORATION | 973.26K | $2.55M | 0.17% | Hold |
| 33 | PACB | PACIFIC BIOSCIENCES CALIF IN | 1.04M | $1.90M | 0.13% | Hold |
| 34 | RXRX | RECURSION PHARMACEUTICALS IN | 165.32K | $1.12M | 0.07% | New |
| 35 | PRME | PRIME MEDICINE INC | 367.18K | $1.07M | 0.07% | Hold |
| 36 | GLUE | MONTE ROSA THERAPEUTICS INC | 86.01K | $596.94K | 0.04% | Hold |
| 37 | DNA | GINKGO BIOWORKS HOLDINGS INC | 36.49K | $358.36K | 0.02% | Hold |
| 38 | KRON | KRONOS BIO INC | 123.84K | $117.65K | 0.01% | Hold |